Biomaxx Energy Nutrition
Vitamin B12- Methylcobalamin Sublingual Spray
The functional and active form of Vitamin B12
WHY BIOMAXX VITAMIN B12-METHYLCOBALAMIN?
Methylcobalamin is the only biologically active form of Vitamin B12 that the body uses directly without any modifications. Other forms of Vitamin B12 are not immediately available to the body and they must be converted into methylcobalamin by the liver. Therefore this can be a significant issue in people with liver disease.
The more common and cheaper form of Vitamin B-12 available without a prescription is cyanocobalamin. It is a synthetic form that does not naturally occur in either plants or animals and must be broken down in the body to a usable form of cobalamin. The byproduct, cyanide, must then be removed from the body by the kidneys and a methyl molecule must then join with the cobalamin before the body can use the B12.
Methylcobalamin is not only better absorbed than cyanocobalamin; it is also retained in higher amounts in the tissues. Methylcobalamin is the specific form of B12 needed for nervous system health and it also helps in the formation of S-adenosylmethionine (SAM-e) a mood-altering compound produced in the liver and also sold as a popular supplement product. In fact some of the benefits of methylcobalamin, such as protection from neurotoxicity and liver disease, appear to be from increased production of the compound SAM-e.
Methylcobalamin is the only form of Vitamin B-12 used by the nervous system. It is a very important nutrient helping to build and maintain the myelin sheath around nerves by carrying methyl groups to the nerve tissue. It is also a powerful brain detoxifier and the natural protective agent against the negative effects of the neurotransmitter glutamate which would otherwise leaves nerves in an excited state. Recent data suggests that methylcobalamin may be beneficial for patients with a variety of different neuropathies. Studies have reported successful use of methylcobalamin in patients suffering from chronic fatigue syndrome and fibromyalgia. Evidence indicates methylcobalamin has other metabolic and therapeutic applications not shared by the other forms of vitamin B12.
WHY VITAMIN B12?
Vitamin B12 is a water soluble vitamin that is essential for good health. It plays an important role in methylation reactions, cellular energy and immune system regulation. It is vital for both the normal functioning of the nervous system and for the formation of red blood cells.
Our bodies are incapable of producing any B12, so it is crucial that we obtain this vitamin from an outside source, either through diet or supplements. Natural food sources of Vitamin B12 are all animal derived and include meat, fish, poultry, eggs, and dairy products. Some cereal and flour products are fortified with B vitamins, including B12 in the form of cyanocobalamin. Unfortunately all our healthy fruits and vegetables contain absolutely zero Vitamin B12.
Vitamin B12 is not easily absorbed into our bodies. There are numerous factors which can contribute to a deficiency of Vitamin B12 in the body. First of all we need to get it into our bodies in some form. Vegetarians are at the greatest risk of developing deficiency at this step because of the lack of animal protein in their diet. Therefore it is imperative that vegetarians supplement their diet with another source of B12.
Malabsorption of the vitamin is a significant cause of B12 deficiency. Adequate absorption is dependent upon normal functioning of the stomach, pancreas and small intestine. Vitamin B12 from food is ingested bound to protein. The B12 must then be released and absorbed into the liver. For this operation to be successful, it is necessary to have sufficient gastric acid. As we age we lose the ability to absorb B12 from our diet due to naturally decreasing levels of stomach acid. Excessive alcohol consumption is another factor that can contribute due to faulty absorption. Medications to reduce stomach acid are a prime contributor to malabsorption of B12 from one’s diet. Metformin is a widely prescribed diabetic medication which is also known to cause B12 deficiency. Some antibiotics and seizure medications can reduce absorption in the small intestine.
In addition to sufficient gastric acid, there must also be adequate intrinsic factor which is produced by the parietal cells in the stomach. It is in the small intestine that the intrinsic factor binds to the B12 through a process involving pancreatic enzymes. The new product exits the small intestine and enters the liver where it is stored until needed. This step can be compromised by a multitude of situations such as surgical removal of the stomach or small intestine, as well as gastric bypass surgery.
The older one gets the more likely one is to develop a vitamin B12 deficiency. The modern day diet of processed foods that so many in developed countries follow eventually causes breakdown of one’s digestive system. The lining of the stomach gradually loses its ability to produce hydrochloric acid, without which vitamin B12 cannot be released from ingested food. Atrophic gastritis is a condition that damages the parietal cells in the stomach and as many as 30 per cent of persons over age 60 may have this condition. Intestinal disorders such as Crohn's disease, celiac disease, and parasites can cause a serious deficiency. Infection with Helicobacter pylori bacteria, a common contributor to stomach ulcers can also result in faulty absorption of dietary B12.
In pernicious anemia, another autoimmune disease, the parietal cells are destroyed by antibodies resulting in non absorption of dietary B12. This disease was 100% fatal at one time. In 1934 the Nobel Prize in Physiology was awarded to Whipple, Minot & Murphy for the discovery that pernicious anemia could be treated with a certain amount of raw liver pulp taken each day by mouth. Eventually the missing nutrient in this disease was discovered to be cobalamin. Fortunately today a more palatable cure is available in the form of injectable Vitamin B12. Recent studies have shown that it can also be treated with high doses of sublingual B12 In the form of methylcobalamin. In two studies, oral treatment with 2 mg per day was as effective as monthly 1 mg injections.
Although many symptoms of B12 deficiency are vague or subtle, full blown Vitamin B12 deficiency can have devastating effects on the body. The B vitamins are synergistic and all are essential for the nervous system to maintain its integrity and function properly. VitaminB12 deficiency alone can cause severe and permanent nervous system damage and/or life threatening anemia and diagnosis is frequently missed.
Pernicous anemia is fatal if undiagnosed or untreated. Long before B12 deficiency shows up as anemia it can manifest in many of our other body systems. The nervous system can be severely effected with extremity pain or weakness, loss of balance, numbness or tingling of extremities, confusion, dementia, memory loss, delusions, depression, strange skin sensations (bugs crawling under skin) or visual disturbances. Hematological symptoms include anemia, fatigue, weakness and shortness of breath. B12 deficiency can affect the immune system resulting in poor wound healing and increased rate of infections. Gastrointestinal symptoms include indigestion, weight loss, malabsorption and constipation. B12 deficiency can contribute to osteoporosis, poor bone density and pathological fractures. Cervical dysplasia and neurogenic bladder can also be a sign of B12 defciency.
In general B12 deficiency is preventable and treatable as long as patients and physicians are aware of signs and symptoms and the importance of testing levels in susceptible patients. Unfortunately that is not always the case. It is important to learn about B12. There are several excellent sources of information for the public. If you have any risk factors for B-12 deficiency, be proactive and supplement your diet with methylcobalamin. B12 deficiency is now so widespread that as many as 40 per cent of all people are affected. You cannot get too much B12 but you can certainly suffer from too little.
Warning:You should not take B12 if you have a family history of Leber’s disease, a hereditary eye disease. It can seriously harm the optic nerve, which might lead to blindness. Do not take B-12 if you have an allergy or sensitivity to cobalt or cobalamin. Consult a physician if you feel you may have symptoms of anemia or dysfunction of the nervous system.
WHY SUBLINGUAL SPRAY?
Sublingual administration provides rapid absorption and onset of action of a substance via blood vessels under the tongue. This area of the oral cavity happens to be the most permeable section of the mouth. The sublingual route also offers advantages such as better bioavailability by bypassing the hepatic first pass metabolic process. It is an excellent solution for people who have difficulty swallowing.
These statements have not been evaluated by the Food and Drug Administration. The products sold on this website are not intended to diagnose, treat, cure or prevent any disease.
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